- Alexander Lemming from The Beano, named after Alexander Fleming
- Ann-Margrock Flintstones character after actress Ann-Margret
- Arnie Pie from The Simpsons is named after Ernie Pyle.
- Arpine Lusène, named after Arsène Lupin, a fictional character from Maurice Leblanc.
- Baby Crockett, from The Beezer comic Davy Crockett
- Baby Face Finlayson, from The Beano comic Baby Face Nelson
- Buzz Lightyear from Toy Story is named after astronaut Buzz Aldrin
- Calamity James from The Beano comic Calamity Jane
- Calvin from Calvin and Hobbes John Calvin, 16th century theologian
- Hobbes from Calvin and Hobbes Thomas Hobbes, 17th century philosopher
- Cary Granite - Flintstones character after actor Cary Grant
- Casey Strangle appeared on The Flintstones, named after Casey Stengel.
- Char Aznable (Mobile Suit Gundam through Char's Counterattack). Rumored to be named after French lounge singer Charles Aznavour.
- Clark Gravel - Flintstones character named after actor Clark Gable.
- Donatello, the second youngest of the ninja turtle brothers from TMNT, was named after the Italian Renaissance artist and sculptor, Donatello
- Egroeg Sacul, Star Tours at the Disney-MGM Studios, named after Star Wars creator George Lucas. Egroeg Sacul is George Lucas spelled backwards.
- Foghorn Leghorn, Warner Brothers cartoons Senator Claghorn, regular character on the Fred Allen radio show
- Frankie Stein, from the Wham!, Shiver and Shake, Whoopee! and Monster Fun comics. Frankenstein
- Dewey, one of "Huey, Dewey and Louie" Thomas Edmund Dewey, American politician
- Helga G. Pataki of "Hey Arnold!", named after former governor George Pataki.
- Huey Freeman from The Boondocks is named after Huey P. Newton
- Huey, one of "Huey, Dewey and Louie" Huey Pierce Long, American politician
- Hitmonlee from Pokémon Bruce Lee, martial artist
- Hitmonchan from Pokémon Jackie Chan, martial artist
- Hohenheim of Light, from Fullmetal Alchemist - Paracelsus, sixteenth-century alchemist, whose real name was Theophrastus Van Hohenheim
- Huckleberry Hound - Huckleberry Finn, The Adventures of Huckleberry Finn
- Ivy the Terrible, from The Beano comic Ivan the Terrible.
- Jane Roberts from The Little Wolf and the Bad Little Girl person of the same name.
- Jesse and James from Pokémon are named after Jesse James.
- Jimmy Darrock, Flinstones character named after singer James Darren.
- John D. Rockerduck, named after John D. Rockefeller.
- Jules and Verne, the sons of Doctor Emmett Brown in Back to the Future: The Animated Series, are named after Jules Verne.
- The Koopalings are named after various famous people.
- Leonardo, the oldest of the ninja turtle brothers from TMNT, was named after the great Italian Renaissance artist and scientist, Leonardo da Vinci
- Leo Ferocious appeared on The Flintstones, named after Leo Durocher.
- Ludwig Von Drake, named after Ludwig van Beethoven.
- Marge Bouvier Simpson, named after Jacqueline Lee Bouvier Kennedy Onassis, former First Lady of the United States, widow to John F Kennedy.
- Michelangelo, the youngest of the ninja turtle brothers from TMNT, was named after the great Italian Renaissance artist and sculptor, Michelangelo Buonarotti
- Milhouse Van Houten from The Simpsons is named after Richard Milhous Nixon, see BBC Simpson's page
- Mickey Mouse, Mickey Rooney claims it was named after him (see cartoon character's page for the official origin).
- Morlocks - in Marvel Comics, a group of mutants naming themselves after the futuristic race in H.G. Wells' The Time Machine
- Mr. Hook from The Little Wolf and the Bad Little Girl Captain Hook, fictional character in J.M. Barrie's Peter Pan.
- Nemo from the movie Finding Nemo Captain Nemo, fictional character in Jules Verne's novels: 20,000 Leagues under the Sea and The Mysterious Island.
- Nero (Flemish Comics), Belgian comic character by Marc Sleen is named after the Roman emperor Nero.
- Oscar from Cerebus named after poet and playwright Oscar Wilde.
- Pepe Le Pew, French skunk in Warner Brothers cartoons Pepe le Moko, fictional character from the novel and movies of the same name
- Philip J. Fry, from Futurama Phil Hartman, voice actor
- Hubert Farnsworth from Futurama Philo Farnsworth
- Scrooge McDuck Ebenezer Scrooge, fictional character in Charles Dickens' A Christmas Carol
- Seymour Skinner is named after B.F. Skinner.
- Raphael, the second oldest of the ninja turtle brothers from TMNT, was named after the Italian Renaissance artist and sculptor, Raphael Sanzio
- Richard the Lion, from The Beano comic Richard the Lionheart
- Rip Van Wink, from The Beano comic Rip van Winkle
- Sigmund (Dutch comics character), named after Sigmund Freud
- Stony Curtis - Flintstones character after actor Tony Curtis
- Sweeny Toddler, from the Shiver and Shake, Whoopee! and Buster comics Named after Sweeney Todd
- Tycho Brahe, from Penny Arcade Tycho Brahe, sixteenth-century astronomer
- Yogi Bear Yogi Berra, baseball player
- Yensid Fantasia named after Walt Disney. Yensid is Disney spelled backwards.
- The Teenage Mutant Ninja Turtles are each named for a Renaissance painter - Raphael, Michelangelo, Donatello, and Leonardo.
- Victor and Hugo, from The Hunchback of Notre Dame (Disney film) - Named after Victor Hugo, author of The Hunchback of Notre Dame
- Wolfgang from Hey Arnold! - Wolfgang Amadeus Mozart
- Ludvig from Hey Arnold! - Ludwig van Beethoven
- Rock Lee from Naruto is named after Bruce Lee.
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